Deploying Prerequisites for 64-bit Applications
ClickOnce deployment supports the installation of applications on 64-bit platforms. The target platforms are x86 for 32-bit platforms, x64 for machines supporting the AMD64 and EM64T instruction sets, and Itanium for the 64-bit Itanium processor.
The following table lists the redistributables that you can use as prerequisites for your 64-bit application's installation.
If you select a prerequisite that does not have 64-bit components, you may see a warning stating that the selected packages are not available for the 64-bit platform.
Visual Studio Tools for Office runtime
Visual C++ 2010 Runtime Libraries (IA64)
Visual C++ 2010 Runtime Libriaries (x64)
Microsoft .NET Framework 4 (x86 and x64)
Microsoft .NET Framework 4 Client Profile (x86 and x64)