Proprietà ObjectDataSource.EnableCaching

<form id="form1" runat="server">
<div>
<asp:objectdatasource
      ID="ObjectDataSource1"
      runat="server"
      SelectMethod="GetFullNamesAndIDs"
      TypeName="Samples.AspNet.CS.EmployeeLogic" />

    <p>
    <asp:dropdownlist
      ID="DropDownList1"
      runat="server" 
      DataSourceID="ObjectDataSource1"
      DataTextField="FullName"
      DataValueField="EmployeeID" 
      AutoPostBack="True" 
      AppendDataBoundItems="true">
        <asp:ListItem Text="Select One" Value=""></asp:ListItem>
    </asp:dropdownlist>
    </p>

 <asp:objectdatasource
      ID="ObjectDataSource2"
      runat="server"
      SelectMethod="GetEmployee"
      TypeName="Samples.AspNet.CS.EmployeeLogic" 
      EnableCaching="true"
      CacheKeyDependency="EmployeeDetails" >
      <SelectParameters>
        <asp:ControlParameter ControlID="DropDownList1" DefaultValue="-1" Name="empID" />
      </SelectParameters>
    </asp:objectdatasource>

    <asp:DetailsView
        ID="DetailsView1"
        runat="server"
        DataSourceID="ObjectDataSource2" 
        AutoGenerateRows="false">  
        <Fields>
            <asp:BoundField HeaderText="Address" DataField="Address" />
            <asp:BoundField HeaderText="City" DataField="City" />
            <asp:BoundField HeaderText="Postal Code" DataField="PostalCode" />
        </Fields>  
    </asp:DetailsView>

    <asp:Button 
    ID="Button1" 
    runat="server" 
    Text="Check for latest data" 
    OnClick="Button1_Click" />

</div>
</form>

protected void Page_Load(object sender, EventArgs e)
{
    if (!IsPostBack)
    {
        Cache[ObjectDataSource2.CacheKeyDependency] = "CacheExample";
    }
}
protected void Button1_Click(object sender, EventArgs e)
{
    Cache.Remove(ObjectDataSource2.CacheKeyDependency);
    Cache[ObjectDataSource2.CacheKeyDependency] = "CacheExample";
    DetailsView1.DataBind();
}

public class EmployeeLogic
{
    public static Array GetFullNamesAndIDs()
    {
        NorthwindDataContext ndc = new NorthwindDataContext();

        var employeeQuery =
            from e in ndc.Employees
            orderby e.LastName
            select new { FullName = e.FirstName + " " + e.LastName, EmployeeID = e.EmployeeID };

        return employeeQuery.ToArray();
    }

    public static Employee GetEmployee(int empID)
    {
        if (empID < 0)
        {
            return null;
        }
        else
        {
            NorthwindDataContext ndc = new NorthwindDataContext();
            var employeeQuery =
                from e in ndc.Employees
                where e.EmployeeID == empID
                select e;

            return employeeQuery.Single();
        }
    }

    public static void UpdateEmployeeAddress(Employee originalEmployee, string address, string city, string postalcode)
    {
        NorthwindDataContext ndc = new NorthwindDataContext();
        ndc.Employees.Attach(originalEmployee, false);
        originalEmployee.Address = address;
        originalEmployee.City = city;
        originalEmployee.PostalCode = postalcode;
        ndc.SubmitChanges();
    }
}