Private Sub dataGridView1_CellMouseEnter(ByVal sender As Object, _
    ByVal e As DataGridViewCellEventArgs) _
    Handles dataGridView1.CellMouseEnter

    Dim markingUnderMouse As Bitmap = _
        CType(dataGridView1.Rows(e.RowIndex). _
            Cells(e.ColumnIndex).Value, Bitmap)

    If markingUnderMouse Is blank Then
        dataGridView1.Cursor = Cursors.Default
    ElseIf markingUnderMouse Is o OrElse markingUnderMouse Is x Then
        dataGridView1.Cursor = Cursors.No
        ToolTip(e)
    End If
End Sub

Private Sub ToolTip( _
    ByVal e As DataGridViewCellEventArgs)

    Dim cell As DataGridViewImageCell = _
        CType(dataGridView1.Rows(e.RowIndex). _
        Cells(e.ColumnIndex), DataGridViewImageCell)
    Dim imageColumn As DataGridViewImageColumn = _
        CType(dataGridView1.Columns(cell.ColumnIndex), _
        DataGridViewImageColumn)

    cell.ToolTipText = imageColumn.Description
End Sub

Private Sub dataGridView1_CellMouseLeave(ByVal sender As Object, _
    ByVal e As DataGridViewCellEventArgs) _
    Handles dataGridView1.CellMouseLeave

    dataGridView1.Cursor = Cursors.Default
End Sub

private void dataGridView1_CellMouseEnter(object sender,
    DataGridViewCellEventArgs e)
{
    Bitmap markingUnderMouse = (Bitmap)dataGridView1.
           Rows[e.RowIndex].
           Cells[e.ColumnIndex].Value;

    if (markingUnderMouse == blank)
    {
        dataGridView1.Cursor = Cursors.Default;
    }
    else if (markingUnderMouse == o || markingUnderMouse == x)
    {
        dataGridView1.Cursor = Cursors.No;
        ToolTip(e, true);
    }
}

private void ToolTip(DataGridViewCellEventArgs e, bool showTip)
{
    DataGridViewImageCell cell = (DataGridViewImageCell)
        dataGridView1
        .Rows[e.RowIndex].Cells[e.ColumnIndex];
    DataGridViewImageColumn imageColumn =
        (DataGridViewImageColumn)
        dataGridView1.Columns[cell.ColumnIndex];

    if (showTip) cell.ToolTipText = imageColumn.Description;
    else { cell.ToolTipText = String.Empty; }
}

private void dataGridView1_CellMouseLeave(object sender,
    DataGridViewCellEventArgs e)
{
    ToolTip(e, false);
    dataGridView1.Cursor = Cursors.Default;
}